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醫師介紹圖片

醫師介紹

科別:
腦血管科
職稱:
科主任
姓名:
李怡慧 I-Hui Lee
現任:
台北榮民總醫院神經內科腦血管科主任
國立陽明大學腦科學研究所副教授
學經歷 :
學經歷
瑞典卡洛林斯卡學院神經科學研究所博士
台北榮民總醫院神經內科專科醫師訓練
國立陽明大學醫學院醫學士

得獎榮譽
2019 腦中風學會優秀論文獎
2017 腦中風學會日新論文獎
2011–2020 台灣陽明大學醫學院優良教師獎(琉璃獎)
2011–2014 台灣神經學會優良壁報獎
2014 腦血管疾病防治基金會高明見教授優秀論文獎
2013 立夫基金會學術獎佳作
2012 台北醫學大學附設阮綜合醫院論文獎第三名
2012 榮台聯大學術論文獎第三名
2012 台北榮總學術論文獎第三名
2008 花蓮玉里榮民醫院優良研究獎
2002–2005 瑞典國際研究及高等教育獎學金及卡洛林斯卡學院博士獎學金

研究興趣
我們的研究興趣是探討台灣年輕型及家族性腦中風的成因和基因-環境的危險因子,以及發展急性到亞急性缺血性中風的積極治療以促進認知和運動功能的恢復,包括: 利用次世代全基因外顯子定序診斷罕見遺傳性腦血管疾病; 嚴重頸動脈狹窄的輕度認知障礙及藥物和介入性治療; 非侵入性經顱刺激術對亞急性中風的癱瘓手恢復的影響等。另外以動物的缺血性中風模型探討成年大腦的神經新生、急性神經保護藥物、和移植人類神經幹/先驅細胞的效果及機制。
學術研究 :

媒體影音報導:

1. 搶救腦中風 (台灣神經學學會廣播Podcast 2018年5月30日)

http://taiwanneurologypodcast.com/episodes 

 

2. 年輕中風增多 (TVBS新聞2017年10月16日)

https://www.youtube.com/watch?v=3AQKCskgZCg&feature=youtu.be 

 

3. 頸動脈狹窄 也可能失智 (公視新聞2014年9月1日)

https://www.youtube.com/watch?v=5zyoDCXl6nc 

 

學術研究:

  1. Kuo IJ#, Tang CW#, Tsai YA, Tang SC, Lin CJ, Hsu SP, Liang WK, Juan CH, Zich C, Stagg CJ, Lee IH*. Neurophysiological signatures of hand motor response to dual-transcranial direct current stimulation in subacute stroke: a TMS and MEG study, Journal of NeuroEngineering and Rehabilitation, 2020;17(1):72.
  2. Chien C, Lin CJ, Chang FC, Chung CP, Lin CJ, MD, Liu HY, Chi NF, Hsu LC, Tang CW, Wang SJ, Guo WY, Luo CB, Lai YJ*, Lee IH*. Quantitative CT Angiography Predicts Large Artery Occlusion Types and Successful Thrombectomy in Acute Ischemic Stroke, Journal of the Chinese Medical Association, 2020, in press.
  3. Tsai LK, Lee IH, Chen YL, Chao TF, Chen YW, Po HL, Lien LM, Chu PH, Huang WC, Lin TH, Lin MT, Jeng JH*, Hwang JJ*. Diagnosis and Treatment for embolic stroke of undetermined source: Consensus statement from the Taiwan stroke society and Taiwan society of cardiology, Journal of the Formosan Medical Association, 2020;S0929-6646(20)30216-3.
  4. Tang CW, Hsiao FJ, Lee PL, Tsai YA, Hsu YF, Chen WT, Lin YY, Lee IH*. β-Oscillations Reflect Recovery of the Paretic Upper Limb in Subacute Stroke, Neurorehabilitation and Neural Repair, 2020;34(5):450–462.
  5. Chen WC, Chang LH, Huang SS, Huang YJ, Chih CL, Kuo KC, Lee YH*, Lee IH*. Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain, Journal of Neuroinflammation, 2019;16(1):187.
  6. Su HH, Wang YH, Chen KM, Lin CW, Lee IH, Li YJ, Huang JY, Tsai SK, Yen JC, Huang SS*. Exogenous GDF11 attenuates non- canonical TGF-β signaling to protect the heart from acute myocardial ischemia– reperfusion injury. Basic Research in Cardiology, 2019;114(3):20.
  7. Tang CW, Hsiao FJ, Lee PL, Tsai YA, Hsu YF, Chen WT, Lin YY, Lee IH*. Beta Oscillation Signatures underlying Recovery of the Paretic Upper Limb in Subacute Stroke, in revision.
  8. Chang LH, Lin HC, Huang SS, Chen IC, Chu KW, Chih CL, Liang YW, Lee YC, Chen YY, Lee YH, Lee IH*. Blockade of soluble epoxide hydrolase attenuates post-ischemic neuronal hyperexcitation and confers resilience against stroke with TrkB activation, Scientific Reports 2018;8(1):118.
  9. Hu YS, Guo WY, Lee IH, Chang FC, Lin CJ, Lin CJ, Luo CB, Wu CC, Lee HJ. Prolonged cerebral circulation time is more associated with symptomatic carotid stenosis than stenosis degree or collateral circulation, J NeuroIntervent Surg 2018;10(5):476-480.
  10. Ho CH, Lin WC, Hsu YF, Lee IH, Hung YC. One-Year Risk of Pneumonia and Mortality in Patients with Poststroke Dysphagia: A Nationwide Population-Based Study. J Stroke Cerebrovascular Diseases 2018;27(5):1311-1317.
  11. Lee IH, Huang SS, Chuang CY, Liao KH, Chang LH, Chuang CC, Su YS, Lin HJ, JY Hsieh, Su SH, Lee OK, Kuo HC*. Delayed epidural transplantation of human induced pluripotent stem cell-derived neural progenitors enhances functional recovery after stroke, Scientific Reports 2017;7(1):1943.
  12. Lin CJ, Chang, FC, Chou KH, Tu PC, Lee YH, Lin, CP, Wang, PN, Lee IH*, Interventionversus Aggressive Medical Therapy for Cognition in Severe Asymptomatic Carotid Stenosis. American Journal of Neuroradiology, 2016;37(10):1889-1897.
  13. Hsu HT, Lee IH, Tsai HT, Chang HC, Shyu KK, Hsu CC, Chang HH, Yeh TK, Chang CT, Hsu PC, Lee PL*, Evaluate the feasibility of using SSVEP to implement an SSVEP-based BCI in Young, Elderly and ALS groups. IEEE Transactions on Neural Systems and Rehabilitation Engineering 2016;24(5):603-15.
  14. Liu PY, Lee IH, Tan PH, Wang YP, Tsai CF, Lin HC, Lee FY, Lu CL*, P2X7 receptor mediates spinal microglia activation of visceral hyperalgesia in a rat model of chronic pancreatitis, Cellular and Molecular Gastroenterology and Hepatology 2015;1:710-720.e715.
  15. Liao YC, Hsiao CT, Fuh JL, Chern CM, Lee WJ, Guo YC, Wang SJ, Lee IH, Liu YT, Wang YF, Chang FC, Chang MH, Soong BW, Lee YC, Characterization of CADASIL among the Han Chinese in Taiwan: Distinct Genotypic and Phenotypic Profiles. PLoS One 2015; 10 (8): e0136501.
  16. Lin CJ, Tu PC, Chern CM, Hsiao FJ, Chang FC, Cheng HL, Tang CW, Lee YC, Chen WT, Lee IH*. Connectivity features for identifying cognitive impairment in presymptomatic carotid stenosis. PLoS ONE 2014; 9 (1): e85441.
  17. Hsu YF, Huang YZ, Lin YY, Liao KK, Lee PL, Tsai YA, Yeh CL, Cheng HL, Cheng H, Chern CM, Lee IH*. Intermittent theta burst stimulation over ipsilesional primary motor cortex of subacute ischemic stroke patients: a pilot study. Brain Stimulation 2013;6(2):166-174.
  18. Huang SS, Cheng H, Tang CM, Nien MW, Huang YS, Lee IH, Yin JH, Kuo TBJ, Yang CCH, Hung YC, Tsai SK*, Yang DI*. Anti-oxidative, anti-apoptotic, and pro-angiogenic effects mediate functional improvement by sonic hedgehog against focal cerebral ischemia in rats. Experimental Neurology, 2013;247:680-88.
  19. Hsieh JY, Wang HW, Chang SJ, Liao KH, Lee IH, Lin WS, Wu CH, Lin WY, Cheng SM. Mesenchymal stem cells from human umbilical cord express preferentially secreted factors related to neuroprotection, neurogenesis, and angiogenesis. PLoS One. 2013;22(8):e72604.
  20. Soong BW, Liao YC, Tu PH, Tsai PC, Lee IH, Chung CP, Lee YC. A homozygous NOTCH3 mutation p.R544C and a heterozygous TREX1 variant p.C99MfsX3 in a family with hereditary small vessel disease of the brain. Journal of the Chinese Medical Association 2013;76:319e324.
  21. Cheng HL, Lin CJ, Soong BW, Wang PN, Chang FC, Wu YT, Chou KH, Lin CP, Tu PC*, Lee IH*. Impairments in cognitive function and brain connectivity in severe asymptomatic carotid stenosis. Stroke, 2012;43(10):2567-73.
  22. Hsu WY, Cheng CH, Liao KK, Lee IH, Lin YY. Effects of repetitive transcranial magnetic stimulation on motor functions in stroke patients: a meta-analysis. Stroke, 2012;43(7):1849-57.
  23. Liu PY, Lu CL, Wang CC, Lee IH, Lee HF, Luo JC, Lin HC, Chang FY, Lee SD. Spinal Microglia Mediate the Maintenance and Initiation of Hyperalgesia in Chronic Pancreatitis. Gastroenterology, 2012;142(1):165-73.
  24. Chang HC, Lee PL, Lo MT, Lee IH, Yeh TK, Chang CY. Independence of amplitude-frequency and phase calibrations in an SSVEP-Based BCI using stepping delay flickering sequences. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2012;20(3):305-12.
  25. Tsai CP, Soong BW, Tu PH, Lin KP, Fuh JL, Tsai PC, Lu YC, Lee IH, Lee YC*. A hexanucleotide repeat expansion in C9ORF72 causes familial and sporadic ALS in Taiwan. Neurobiology of Aging, 2012; 33(9):2232.e11-8.
  26. Hsu YF, Liao KK, Lee PL, Tsai YA, Yeh CL, Lai KL, Huang YZ, Lin YY, Lee IH*. Intermittent theta burst stimulation over primary motor cortex enhances movement- related beta synchronization. Clinical Neurophysiology, 2011; 122(11): 2260-7.
  27. Tang CW, Chang FC, Chern CM, Lee YC, Hu HH, Lee IH*. Stenting versus medical treatments for severe symptomatic intracranial stenosis. American Journal of Neuroradiology, 2011; 32(5): 911-6.
  28. Lee YC, Liao YC, Wang PS, Lee IH, Lin, KP, Soong BW. Comparison of Cerebellar Ataxias: a Three-Year Prospective Longitudinal Assessment. Movement Disorders, 2011; 26(11): 2081-7.
  29. Lin KP, Soong BW, Yang CC, Huang LW, Chang MH, Lee IH, Antonellis A, Lee YC. The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan. PLoS ONE, 2011; 6(12): e29393.
  30. Huang MC, Chang PT, Tsai MJ, Kuo HS, Kuo WC, Lee MJ, Lo MJ, Lee IH, Huang WC, Lee LM, Shih YH, Lee LS, Cheng H. Sensory and motor recovery after repairing transected cervical roots. Surgical Neurology 2007 Nov; 68, S17-S24.
  31. Johansson S*, Lee IH, Olson L, Spenger C. Olfactory ensheathing glial co-grafts improve functional recovery in 6-OHDA lesioned rats. Brain, 2005; 128 (12), 2961-2976.
  32. Lee IH*, Lindqvist E, Kiehn O, Widenfalk J, Olson L. Glial and neuronal connexin expression patterns in the rat spinal cord during development and following injury. Journal of Comparative Neurology 2005 Aug; 489 (1): 1-10.
  33. Lee IH*, Bulte JWM, Schweinhardt P, Douglas T, Trifunovski A, Hofstetter C, Olson L, Spenger C. In vivo magnetic resonance tracking of olfactory ensheathing glia grafted into the rat spinal cord. Experimental Neurology 2004 Jun; 187(2): 509-516.
  34. Lee LM, Huang MC, Chuang TY, Lee LS, Cheng H, Lee IH*. Acidic FGF enhances functional regeneration of adult dorsal roots. Life Sciences 2004 Feb; 74 (15): 1937-1943.
  35. Lee IH, Lu YC, Chang YC, Soong BW*. Dentatorubral-Pallidoluysian atrophy in Chinese. Archives of Neurology 2001 Nov; 58(11):1905-1908
  36. Lee IH*, Kwan SY, Su MS. Eating seizures in Lennox-Gastaut syndrome. European Neurology 2001;45(2):123-125.