醫師介紹
科別:
周邊神經科
職稱:
主治醫師
姓名:
季康揚
現任:
台北榮民總醫院神經內科主治醫師
國立陽明交通大學生理學研究所助理教授
國立陽明交通大學生理學研究所助理教授
學經歷 :
國立陽明大學醫學士
美國密蘇里大學生理學博士
台北榮民總醫院神經內科住院醫師，總醫師
臺北榮民總醫院桃園分院神經內科主治醫師
臨床專長: 神經肌肉疾病、周邊神經疾病，運動神經元疾病、動作障礙，家族性腦中風，神經基因學
美國密蘇里大學生理學博士
台北榮民總醫院神經內科住院醫師，總醫師
臺北榮民總醫院桃園分院神經內科主治醫師
臨床專長: 神經肌肉疾病、周邊神經疾病，運動神經元疾病、動作障礙，家族性腦中風，神經基因學
學術研究 :
研究方向：運動神經元疾病（漸凍症），遺傳性神經疾病
得獎紀錄
2019 臺北市醫師公會第八屆青年杏林獎
2018年台灣神經學學會年會「優秀壁報論文金牌獎」
2017,2018 臺北榮民總醫院最佳教學住院醫師
學術研究 :
- Tsai MF, Jih KY, Shimizu H, Li M, Hwang TC. Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels. J Biol Chem. 2010;285(48):37663-37671.
- Jih KY, Li M, Hwang TC, Bompadre SG. The most common cystic fibrosis-associated mutation destabilizes the dimeric state of the nucleotide-binding domains of CFTR. J Physiol. 2011;589(Pt 11):2719-2731.
- Jih KY, Hwang TC. Nonequilibrium gating of CFTR on an equilibrium theme. Physiology (Bethesda). 2012;27(6):351-361.
- Jih KY, Sohma Y, Hwang TC. Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation. J Gen Physiol. 2012;140(4):347-359.
- Jih KY, Sohma Y, Li M, Hwang TC. Identification of a novel post-hydrolytic state in CFTR gating. J Gen Physiol. 2012;139(5):359-370.
- Jih KY, Hwang TC. Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle. Proc Natl Acad Sci U S A. 2013;110(11):4404-4409.
- Lin WY, Jih KY, Hwang TC. A single amino acid substitution in CFTR converts ATP to an inhibitory ligand. J Gen Physiol. 2014;144(4):311-320.
- Jih KY, Lin WY, Sohma Y, Hwang TC. CFTR potentiators: from bench to bedside. Curr Opin Pharmacol. 2017;34:98-104.
- Jih KY, Chung CP, Chang YY, et al. Mutational analysis of CCM1, CCM2 and CCM3 in a Han Chinese cohort with multiple cerebral cavernous malformations in Taiwan. Clin Genet. 2018;94(3-4):389-390.
- Tsai PC, Liao YC, Jih KY, Soong BW, Lin KP, Lee YC. Genetic analysis of ANXA11 variants in a Han Chinese cohort with amyotrophic lateral sclerosis in Taiwan. Neurobiol Aging. 2018;72:188 e181-188 e182.
- Chou CT, Soong BW, Lin KP, Tsai YS, Jih KY, Liao YC, et al. Clinical characteristics of Taiwanese patients with Hereditary spastic paraplegia type 5. Ann Clin Transl Neurol. 2020;7(4):486-96.
- Jih KY, Lin KP, Tsai PC, Soong BW, Liao YC, Lee YC. Investigating TBP CAG/CAA trinucleotide repeat expansions in a Taiwanese cohort with ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2020:1-6.
- Jih KY, Tsai PC, Tsai YS, Liao YC, Lee YC. Rapid progressive ALS in a patient with a DNAJC7 loss-of-function mutation. Neurol Genet. 2020;6(5):e503.
- Tsai YS, Lin KP, Jih KY, Tsai PC, Liao YC, Lee YC. Hand-onset weakness is a common feature of ALS patients with a NEK1 loss-of-function variant. Ann Clin Transl Neurol. 2020;7(6):965-71.
- Jih KY, Chou YT, Tsai PC, et al. Analysis of NOTCH2NLC GGC repeat expansion in Taiwanese patients with amyotrophic lateral sclerosis. Neurobiol Aging 2021;108:210-12.
- Liao YC, Chang FP, Huang HW, et al. GGC Repeat Expansion of NOTCH2NLC in Taiwanese Patients With Inherited Neuropathies. Neurology 2021 doi: 10.1212/WNL.0000000000013008 [published Online First: 2021/10/23]
- Tsai PC, Jih KY, Shen TY, et al. Genetic and Functional Analysis of Glycosyltransferase 8 Domain-Containing Protein 1 in Taiwanese Patients With Amyotrophic Lateral Sclerosis. Neurol Genet 2021;7(6):e627.
- Hsu SL, Jih KY, Lin KP, et al. Assessing the NOTCH2NLC GGC repeat expansion in Taiwanese patients with hereditary spastic paraplegia. Parkinsonism Relat Disord 2022;96:43-44.
